Amidst the rapid evolution and adoption of generative AI, highlighted by tools such as ChatGPT and advanced visual AI generators, the mainframe industry stands at a pivotal juncture, poised to harness AI to revolutionize its capabilities. As mainframe decision-makers face mounting pressures from the surge in demand for faster and more innovative digital services, AI offers promising solutions to enhance efficiency, predict system needs, and manage escalating data volumes and fluctuating workloads. Hosts Alan Shimel and John Mertic are joined by Michael Curry (Rocket Software), Keelia Estrada-Moeller (Broadcom) and Andrew Sica (IBM) to discuss how this integration could dramatically increase the responsiveness and agility of mainframes, helping to meet heightened customer expectations and the fast-paced deployment of new services, and how the key to success lies in formulating a strategic, goal-oriented approach that utilizes AI not merely as a technological upgrade but as a transformative tool to reshape mainframe operations and sustain their crucial role in the digital age.